*The use of Remdesivir for COVID-19 was authorized by the FDA based on a single RCT, conducted by NIAID with the participation of Gilead Sciences, the exclusive manufacturer of Remdesivir. A final report from this study was published on October 8, five months after the drug’s authorization.
*The final report shows that at least 35% of the patients were treated with Hydroxychloroquine, probably with Azithromycin. The data in the final report suggests that Hydroxychloroquine, not Remdesivir, was the main factor benefitting the patients in this study.
*Nothing in the study supports the hypothesis that Remdesivir is an effective antiviral for SARS-COV-2.
*The study’s own numbers show an association between RDV and increased mortality in the most severe patients. It is also possible to conclude that RDV is net harmful for most hospitalized patients.
*The trial was conducted and reported with multiple defects, including:
*The study was not double blind, but was reported as such
*The pre-registered protocol was changed multiple times over the course of the trial
*The primary outcome was changed in the middle of the trial, apparently because the researchers noticed a lack of effectiveness of their drug as tried
*The outcome measures were subjective and not reliable
*The study was marred with conflicts of interest, aggravated by the design giving NIAID and Gilead leverage over the hospitals and physicians treating patients
*At least three of the study researchers-authors failed to report grants and/or personal fees received from Gilead recently.
https://wattsupwiththat.com/2020/10/...xychloroquine/